Description

4-Hydroxypiperidine is a versatile heterocyclic building block and intermediate of significant importance in advanced organic synthesis. Its bifunctional nature, featuring both a secondary amine and a hydroxyl group, makes it a critical scaffold for constructing complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediates: Key building block for the synthesis of various drug candidates, including central nervous system (CNS) agents, receptor antagonists, and enzyme inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer Chemistry: Acts as a monomer or chain modifier in the production of specialty polyamides and other performance polymers.
• Chemical Research: Fundamental reagent in methodological development and medicinal chemistry for constructing piperidine-based libraries.
• Complex Natural Product Synthesis: Employed as a synthon in the total synthesis of alkaloids and other natural products containing the piperidine moiety.

Basic Information

Item	Detail
Product Name	4-Hydroxypiperidine
CAS No.	5382-16-1
Molecular Formula	C5H11NO
Molecular Weight	101.15 g/mol
Synonyms	4-Piperidinol; 4-Hydroxypiperidine; 4-Piperidinyl alcohol; 1,2,3,6-Tetrahydropyridin-4-ol; Piperidin-4-ol; 4-Hydroxy-piperidine; 4-Piperidol; NSC 403697
EINECS	226-355-8

Quality Control

Our 4-Hydroxypiperidine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, water content, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, the container should be kept tightly sealed after each use to minimize exposure to atmospheric moisture. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Melting Point	86 - 90 °C
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.