Description

4-(4-(4-(4-(((3S,5S)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3R)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one is a sophisticated chiral organic compound featuring a complex molecular architecture with multiple heterocyclic and aryl components. This compound is of significant interest for its potential as a high-value pharmaceutical intermediate or active pharmaceutical ingredient (API) precursor, particularly in the development of novel antifungal or other therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in advanced synthetic chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antifungal or other small-molecule therapeutics.
• Drug Discovery Research: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Chemical Reference Standard: Serves as a high-purity analytical standard for method development and quality control in API manufacturing.
• Preclinical Development: Employed in the production of batches for pharmacological and toxicological evaluation.
• Academic Research: Utilized in university and institutional labs for studying advanced organic synthesis methodologies and heterocyclic chemistry.
• Process Chemistry: Acts as a critical intermediate for scaling up synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	4-(4-(4-(4-(((3S,5S)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3R)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one
CAS No.	2243785-98-8
Molecular Formula	C39H42F2N8O4
Molecular Weight	724.80 g/mol
Synonyms	(3S,5S)-5-[(1H-1,2,4-Triazol-1-yl)methyl]-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl 4-[4-[4-[1-[(2S,3R)-2-hydroxypentan-3-yl]-5-oxo-1H-1,2,4-triazol-4-yl]phenyl]piperazin-1-yl]phenyl ether; UNII-Contact for details; CAS 2243785-98-8; Complex Triazolone-Tetrahydrofuran-Piperazine Derivative; Antifungal Candidate Intermediate (Proposed); Bis-triazolyl Piperazine Ether
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and development purposes. Quality is verified through comprehensive analytical techniques including HPLC, chiral analysis, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, chiral purity, and impurity profiles. We support compliance with ICH guidelines for impurities and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.