Description

tert-Butyl ((R)-4-Oxo-4-(((R)-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)amino)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate is a sophisticated, high-purity chiral intermediate featuring a complex triazolopyrazine core and multiple fluorinated aromatic groups. This compound is of significant value in modern pharmaceutical research and development, particularly as a key building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries working on targeted therapies, including enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting metabolic or neurological disorders.
• Protease Inhibitor Research: The structural motifs present make it a valuable precursor for developing inhibitors of specific proteases and kinases.
• Fluorinated Compound Library Synthesis: Used in medicinal chemistry to create focused libraries of fluorinated compounds for high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for potential APIs under Good Manufacturing Practice (GMP) conditions.
• Bioconjugation & Probe Development: The reactive handles can be utilized for creating chemical probes for biological target identification and validation.

Basic Information

Product Name	tert-Butyl ((R)-4-Oxo-4-(((R)-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)amino)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
CAS No.	2088771-62-2
Molecular Formula	C₃₃H₃₃F₉N₆O₅
Molecular Weight	788.65 g/mol
Synonyms	(R)-tert-Butyl (4-oxo-4-(((R)-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)amino)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate; BOC-Protected Triazolopyrazine Intermediate; (R,R)-Boc-DiFluoroTriazoloPyrazine Diamide; 7,8-Dihydro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine-5-carboxamide Derivative; Fluorinated Triazolopyrazine Building Block; CAS 2088771-62-2
EINECS	Contact for details

Quality Control

Our tert-Butyl ((R)-4-Oxo-4-(((R)-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)amino)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development with custom purity grades and can align with GMP guidelines for advanced clinical stage projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.