Description

4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]- is a sophisticated, multi-functional synthetic compound featuring a complex polyamide core decorated with multiple protected N-acetylgalactosamine (GalNAc) moieties. Its molecular architecture is engineered for high-affinity, multivalent binding to specific biological targets, making it a critical intermediate in advanced therapeutic development. This product is essential for pharmaceutical R&D teams and bioconjugation specialists working on next-generation targeted drug delivery systems, particularly in oncology and genetic medicine.

Application

• Bioconjugation Linker: Serves as a sophisticated, branched linker for attaching therapeutic payloads (e.g., siRNA, toxins, chemotherapeutic agents) to targeting ligands like antibodies or peptides.
• GalNAc-Cluster Synthesis: Acts as a key building block for constructing multivalent GalNAc clusters used to target the asialoglycoprotein receptor (ASGPR) on hepatocytes for liver-specific drug delivery.
• Advanced Drug Delivery Systems: A critical intermediate in the development of ligand-directed therapeutics, including Antibody-Drug Conjugates (ADCs) and other targeted prodrugs.
• Pharmaceutical Research: Used in exploratory research to study receptor clustering, endocytosis, and the structure-activity relationships of multivalent interactions.
• Diagnostic Probe Development: Can be utilized to create targeted imaging agents for research and diagnostic applications.
• Biomaterial Functionalization: Employed to introduce bioactive, carbohydrate-based recognition sites onto surfaces or polymers for cell-specific interactions.

Basic Information

Item	Details
Product Name	4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-
CAS No.	1159408-64-6
Molecular Formula	C84H138N10O38
Molecular Weight	1871.99 g/mol (Contact for details)
Synonyms	Tri-GalNAc Branched Linker; Multivalent GalNAc-Amine Linker; ASGPR-Targeting Trimer Scaffold; N-[3-[[1-Oxo-5-[(3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl)oxy]pentyl]amino]propyl]-6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[(3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl)oxy]pentyl]amino]propyl]amino]propoxy]methyl]-4,8-dioxa-12,16-diazaheneicosanamide-21-yl 3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranoside; GalNAc3-Linker-NH2; Tris-GalNAc NHS Ester precursor
EINECS	Contact for details

Quality Control

This high-value synthetic intermediate is produced under strict GMP-like conditions for research use. Every batch undergoes comprehensive analytical characterization to ensure structural integrity and purity. Standard quality checks include HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications. We support custom synthesis and purity requirements to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dedicated, dry freezer. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage (over 6 months), maintain at -80°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms (M+Na+ or M+H+)
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.