Description

(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl]-6-[(1S)-1-methylpropyl]-2,5-piperazinedione benzenesulfonic acid is a high-purity, non-natural amino acid derivative and a key chiral building block designed for advanced pharmaceutical synthesis. This compound is critical for research and development in medicinal chemistry, particularly for creating novel therapeutic agents with specific stereochemical requirements. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used as a building block in structure-activity relationship (SAR) studies and lead optimization to explore new chemical entities.
• Peptidomimetic Development: Its piperazinedione core makes it valuable for designing and synthesizing peptidomimetics and constrained peptides.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric synthesis due to its multiple stereogenic centers, enabling the construction of complex molecular architectures.
• Process Chemistry & Scale-Up: Suitable for process development from milligram to kilogram scale under current Good Manufacturing Practice (cGMP) guidelines for pre-clinical and clinical trial material supply.
• Reference Standard: Can be supplied as a high-purity analytical reference standard for quality control and method development in API manufacturing.

Basic Information

Product Name	(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl]-6-[(1S)-1-methylpropyl]-2,5-piperazinedione benzenesulfonic acid
CAS No.	1159097-48-9
Molecular Formula	C36H44N4O6S
Molecular Weight	660.82 g/mol
Synonyms	BMS-986142; BMS 986142; (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl]-6-[(1S)-1-methylpropyl]-2,5-piperazinedione benzenesulfonate; Tyk2 Inhibitor BMS-986142; BMS986142; 2,5-Piperazinedione, 3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl]-6-[(1S)-1-methylpropyl]-, benzenesulfonate (1:1); (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl]-6-[(1S)-1-methylpropyl]piperazine-2,5-dione benzenesulfonic acid
EINECS	Contact for details

Quality Control

Our (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl]-6-[(1S)-1-methylpropyl]-2,5-piperazinedione benzenesulfonic acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use and stored under an inert atmosphere if necessary for long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.