Description

(5S)-5-[(2R)-2-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]propyl]-3-methylideneoxolan-2-one is a high-purity, complex organic compound with a defined stereochemistry, serving as a critical advanced intermediate in pharmaceutical synthesis. Its precise molecular architecture makes it an essential building block for the development of novel therapeutic agents, particularly in the synthesis of vitamin D analogs and other steroidal compounds. This product is primarily targeted at research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities and high-value active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of vitamin D3 analogs and related secosteroids.
• API Development: Used as a critical building block in the research and process development of new Active Pharmaceutical Ingredients (APIs) targeting bone metabolism, immune modulation, and oncology.
• Process Chemistry: Employed in route scouting and optimization for the commercial-scale production of complex steroidal molecules.
• Chemical Research: Serves as a valuable reference standard and starting material in academic and industrial research exploring novel synthetic pathways and biological activity.
• Custom Synthesis: A foundational component for contract research and manufacturing organizations (CROs/CMOs) offering bespoke synthesis services for client-specific molecules.

Basic Information

Product Name	(5S)-5-[(2R)-2-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]propyl]-3-methylideneoxolan-2-one
CAS No.	173388-20-0
Molecular Formula	C30H40O4
Molecular Weight	464.64 g/mol
Synonyms	Vitamin D3 Intermediate; (5S,2'R,1'R,3a'S,4'E,7a'R,2''Z,3''S,5''R)-5-[2'-[4'-[(2''Z)-2''-[(3'',5''-Dihydroxy-2''-methylidenecyclohexylidene)]ethylidene]-7a'-methyl-2',3',3a',5',6',7'-hexahydro-1'H-inden-1'-yl]propyl]-3-methylideneoxolan-2-one; Secosteroid Intermediate; 1,25-Dihydroxyvitamin D3 Synthetic Precursor; Calcitriol Analog Intermediate; (23S,25R)-1α,25-Dihydroxyvitamin D3 26,23-lactone precursor
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical research and development. The product undergoes comprehensive analytical characterization using HPLC, GC, NMR, and MS to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each batch, documenting all critical quality attributes. We support development projects requiring compliance with ICH Q7 guidelines and can tailor specifications to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.