Description

cis-Vitamin K1 is the biologically active cis-isomer of phylloquinone, a fat-soluble vitamin essential for blood coagulation and bone metabolism. Its high purity and defined stereochemistry are critical for ensuring predictable biological activity and efficacy in pharmaceutical formulations. This compound is primarily required by manufacturers in the pharmaceutical, nutraceutical, and advanced research sectors for producing injectable solutions, oral supplements, and clinical study materials.

Application

• Pharmaceutical Active Ingredient: Key raw material in the production of injectable and oral formulations for the treatment and prevention of vitamin K deficiency bleeding (VKDB).
• Nutraceutical & Dietary Supplements: Used in high-quality vitamin K supplements and multivitamin complexes targeting bone and cardiovascular health.
• Clinical Research & Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control testing in laboratories.
• Animal Feed & Veterinary Medicine: Incorporated into premixes and specialized feeds to prevent hemorrhagic disorders in livestock and poultry.
• Cosmeceutical Formulations: Explored in topical applications for its potential role in skin health and reducing the appearance of dark circles.

Basic Information

Product Name	cis-Vitamin K1
CAS No.	16033-41-3
Molecular Formula	C₃₁H₄₆O₂
Molecular Weight	450.70 g/mol
Synonyms	Phylloquinone; Phytomenadione; Vitamin K1; 2-Methyl-3-phytyl-1,4-naphthoquinone; 3-Phytylmenadione; Konakion; AquaMEPHYTON; Mephyton; (2E,7R,11R)-3-methyl-2-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]naphthalene-1,4-dione
EINECS	240-137-3

Quality Control

Our cis-Vitamin K1 is manufactured under strict quality management systems. Each batch is tested to meet high-purity standards, with specifications aligning with major pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA), detailing assay, isomer purity, and impurity profiles, is provided with every shipment to ensure full traceability and compliance for your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen) at a controlled room temperature of 15-25°C (59-77°F) to minimize oxidation. Keep the container in a cool, dry, and well-ventilated area, away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange, clear, viscous oil
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (cis-Vitamin K1)
Isomer Purity (cis-isomer)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.