Description

Vitamin E Nicotinate is a potent, fat-soluble compound formed by the esterification of Vitamin E (d-α-tocopherol) with nicotinic acid (Vitamin B3). This unique molecular structure combines the antioxidant and cell-protective benefits of tocopherol with the vasodilatory and skin-conditioning properties of niacin. It is a highly sought-after ingredient for advanced formulations in the pharmaceutical and high-end personal care industries, where stability and targeted efficacy are paramount. Key markets include manufacturers of cardiovascular supplements, anti-aging cosmeceuticals, and specialized dermatological treatments.

Application

• Pharmaceutical Intermediates & Active Ingredients: Used in the synthesis of advanced pharmaceutical formulations targeting circulatory health and antioxidant therapy.
• Cosmeceuticals & Anti-Aging Skincare: A key active in serums, creams, and lotions for its ability to improve skin microcirculation, enhance barrier function, and provide antioxidant protection against environmental stressors.
• Dietary Supplements & Nutraceuticals: Incorporated into capsules and softgels for cardiovascular support, leveraging its potential vasodilatory and cholesterol-managing effects.
• Hair Care Formulations: Used in treatments and serums to promote scalp circulation and improve hair follicle health.
• Functional Food Fortification: For the enrichment of specific health-focused food products, pending regulatory approval in the target market.
• Research & Development: Serves as a critical reference standard and raw material in biochemical and pharmacological research.

Basic Information

Product Name	Vitamin E Nicotinate
CAS No.	16676-75-8
Molecular Formula	C35H53NO3
Molecular Weight	535.80 g/mol
Synonyms	d-α-Tocopheryl Nicotinate; Tocopheryl Nicotinate; Vitamin E Niacinate; Nicotinic Acid Tocopherol Ester; Tocopherol Nicotinate; DL-α-Tocopheryl Nicotinate; 2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol Nicotinate; 3-Pyridinecarboxylic Acid, 6-Chromanol Ester
EINECS	240-722-6

Quality Control

Our Vitamin E Nicotinate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for assay and purity, to ensure it meets stringent specifications for pharmaceutical and cosmetic use. We provide full traceability and support our products with detailed Certificates of Analysis (COA). Our quality commitment aligns with cGMP principles, and we can support documentation for regulatory submissions including DMFs, as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen) for long-term stability. Keep away from strong oxidizing agents and excessive heat.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder or waxy solid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Melting Point	38 - 42 °C
Heavy Metals (as Pb)	≤ 10 ppm
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.