Description

[(3S)-oxolan-3-yl] N-[(2S,3S)-4-[(2S)-2-benzyl-4-[(2S)-4-[(1R)-1-carbamoyl-2-phenyl-ethyl]-2-(2-methylpropyl)-3-oxo-1H-pyrrol-2-yl]-3-oxo-1H-pyrrol-2-yl]-3-hydroxy-1-phenyl-butan-2-yl]carbamate is a sophisticated, high-purity synthetic intermediate characterized by its complex, stereochemically defined molecular architecture. This compound is critical for advanced pharmaceutical research and development, particularly in the synthesis of novel therapeutic agents targeting complex biological pathways. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing peptide mimetics and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for protease inhibitors and other enzyme-targeted therapies.
• Peptidomimetic Research: Serves as a core scaffold for developing peptide mimetics with enhanced metabolic stability and bioavailability.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization campaigns for drug discovery programs.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale under current Good Manufacturing Practice (cGMP) guidelines.
• Bioconjugation: Potential use in creating targeted drug conjugates or diagnostic agents due to its functionalizable groups.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) settings for cutting-edge chemical biology and therapeutic research.

Basic Information

Product Name	[(3S)-oxolan-3-yl] N-[(2S,3S)-4-[(2S)-2-benzyl-4-[(2S)-4-[(1R)-1-carbamoyl-2-phenyl-ethyl]-2-(2-methylpropyl)-3-oxo-1H-pyrrol-2-yl]-3-oxo-1H-pyrrol-2-yl]-3-hydroxy-1-phenyl-butan-2-yl]carbamate
CAS No.	173240-66-9
Molecular Formula	C46H52N4O7
Molecular Weight	772.94 g/mol
Synonyms	(3S)-Tetrahydrofuran-3-yl (2S,3S)-4-[(2S)-2-benzyl-4-[(2S)-4-[(1R)-1-carbamoyl-2-phenylethyl]-2-isobutyl-3-oxopyrrol-1-yl]-3-oxopyrrol-1-yl]-3-hydroxy-1-phenylbutan-2-ylcarbamate; CAS 173240-66-9; Oxolan-3-yl carbamate derivative; Pyrrolidinone-based peptide intermediate; Stereoisomeric pharmaceutical building block; Complex heterocyclic carbamate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical R&D and pre-clinical development. Each batch is characterized and released based on comprehensive analytical data, including HPLC purity, chiral purity to confirm stereochemical integrity, and identification by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, impurity profile, and residual solvents. We support development under quality agreements and can align with ICH guidelines for impurities and stability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed in a dry environment and opened only under controlled conditions to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.