Description

5-[3(R)-[[(1,1-Dioxotetrahydrothienyl-3(S)-oxy)carbonyl]amino]-4-(phenylthio)-2(R)-hydroxybutyl]-N-(1,1-dimethylethyl)octahydrothieno[3,2-c]pyridine-6(R)-carboxamide is a high-purity, advanced pharmaceutical intermediate with a complex stereochemistry that is critical for its biological activity. This compound is essential for the synthesis of specific protease inhibitors, offering a key building block for targeted therapeutic development. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of specific protease inhibitor drugs.
• Research & Development: Used in medicinal chemistry for the discovery and optimization of new therapeutic candidates targeting specific enzyme pathways.
• Process Chemistry: Serves as a key chiral building block for scaling up API production under current Good Manufacturing Practice (cGMP) conditions.
• Biochemical Research: Employed as a reference standard or tool compound in enzymatic studies and mechanism-of-action research.
• Custom Synthesis: Utilized by contract research and manufacturing organizations (CRAMOs) for bespoke client projects requiring complex heterocyclic chemistry.

Basic Information

Item	Details
Product Name	5-[3(R)-[[(1,1-Dioxotetrahydrothienyl-3(S)-oxy)carbonyl]amino]-4-(phenylthio)-2(R)-hydroxybutyl]-N-(1,1-dimethylethyl)octahydrothieno[3,2-c]pyridine-6(R)-carboxamide
CAS No.	169273-51-2
Molecular Formula	C27H39N3O5S3
Molecular Weight	597.80 g/mol
Synonyms	Boc-D-Thienylalanine Sulfone Derivative; (3R,6R)-5-[(3R)-3-[[(3S)-1,1-Dioxo-1λ⁶-thiolan-3-yl]oxycarbonylamino]-4-(phenylsulfanyl)-2-hydroxybutyl]-N-tert-butyloctahydrothieno[3,2-c]pyridine-6-carboxamide; 169273-51-2; Advanced Protease Inhibitor Intermediate; tert-Butyl (3R,6R)-5-[(3R)-3-[[(3S)-1,1-dioxothiolan-3-yl]oxycarbonylamino]-4-(phenylthio)-2-hydroxybutyl]octahydrothieno[3,2-c]pyridine-6-carboxylate (related ester); Chiral Thienopyridine Carboxamide.
EINECS	Contact for details

Quality Control

Our 5-[3(R)-[[(1,1-Dioxotetrahydrothienyl-3(S)-oxy)carbonyl]amino]-4-(phenylthio)-2(R)-hydroxybutyl]-N-(1,1-dimethylethyl)octahydrothieno[3,2-c]pyridine-6(R)-carboxamide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure high chemical and isomeric purity suitable for pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; the container should be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.