Description

Carbamic acid, [3-[4-[(2-chloro-6-methyl-4-pyridinyl)methyl]-2-[[(1,1- dimethylethyl)amino]carbonyl]-1-piperazinyl]-2-hydroxy-1-(phenylmethyl )propyl]-, tetrahydro-2-(1-methylethyl)-1,1-dioxido-3-thienyl ester, [ 2R-[2a,3a[1S*,2R*,3(S*)]]]- is a complex, high-purity synthetic intermediate with a defined stereochemistry, identified by CAS No. 159565-70-5. This compound is of significant value for its role in the synthesis of advanced pharmaceutical agents, particularly those targeting specific enzymatic pathways. It is primarily needed by research institutions and pharmaceutical development companies engaged in the creation of novel therapeutic candidates.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of proprietary active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new drug discovery programs.
• Process Chemistry Development: Serves as a key chiral intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Protease Inhibitor Synthesis: Potential application in the development of inhibitors for specific protease enzymes, given its structural motifs.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method validation in analytical laboratories.
• Custom Synthesis: Available for contract manufacturing and custom synthesis projects requiring this specific molecular entity.

Basic Information

Product Name	Carbamic acid, [3-[4-[(2-chloro-6-methyl-4-pyridinyl)methyl]-2-[[(1,1- dimethylethyl)amino]carbonyl]-1-piperazinyl]-2-hydroxy-1-(phenylmethyl )propyl]-, tetrahydro-2-(1-methylethyl)-1,1-dioxido-3-thienyl ester, [ 2R-[2a,3a[1S*,2R*,3(S*)]]]-
CAS No.	159565-70-5
Molecular Formula	C36H48ClN5O6S
Molecular Weight	714.31 g/mol
Synonyms	BMS-232632 Intermediate; Atazanavir Sulfate Intermediate; (2R,3S)-N-tert-Butyl-2-hydroxy-3-[(2S)-2-[(2R,3S)-3-[(tetrahydro-2-isopropyl-1,1-dioxido-3-thienyl)oxycarbonyl]amino-4-phenylbutyl]-4-(2-chloro-6-methyl-4-pyridylmethyl)piperazin-1-yl]-4-phenylbutyramide; 159565-70-5; Carbamic acid, N-[(1S,2R)-3-[[4-[(2-chloro-6-methyl-4-pyridinyl)methyl]-1-piperazinyl]-(2R)-2-hydroxy-1-(phenylmethyl)propyl]-, 2-(1-methylethyl)-1,1-dioxido-3-thienyl ester; Atazanavir related compound.
EINECS	Contact for details

Quality Control

Our Carbamic acid, [3-[4-[(2-chloro-6-methyl-4-pyridinyl)methyl]-2-[[(1,1- dimethylethyl)amino]carbonyl]-1-piperazinyl]-2-hydroxy-1-(phenylmethyl )propyl]-, tetrahydro-2-(1-methylethyl)-1,1-dioxido-3-thienyl ester is manufactured under strict quality systems. Products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and isomeric purity suitable for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each batch to ensure traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storage at 2-8°C. Keep container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.