Description

(4R,5R,6S)-6-(1-hydroxyethyl)-3-[(3S,5S)-5-[(1R)-1-hydroxy-3-methylamino-propyl]pyrrolidin-3-yl]sulfanyl-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid is a sophisticated carbapenem derivative, representing a key advanced intermediate in the synthesis of modern β-lactam antibiotics. Its complex stereochemistry and functional groups make it a critical building block for developing potent antibacterial agents with enhanced stability and efficacy. This high-purity intermediate is essential for pharmaceutical R&D and manufacturing sectors focused on next-generation anti-infective therapies.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of novel carbapenem-class antibiotics.
• Antibacterial Drug Development: Serves as a key scaffold for research into new agents targeting multi-drug resistant (MDR) bacterial infections.
• Chemical Synthesis Research: Used in academic and industrial laboratories for studying β-lactam chemistry and structure-activity relationships (SAR).
• Process Chemistry & Scale-Up: Employed in the development and optimization of commercial-scale manufacturing routes for active pharmaceutical ingredients (APIs).
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory filings in pharmaceutical production.

Basic Information

Product Name	(4R,5R,6S)-6-(1-hydroxyethyl)-3-[(3S,5S)-5-[(1R)-1-hydroxy-3-methylamino-propyl]pyrrolidin-3-yl]sulfanyl-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
CAS No.	149951-16-6
Molecular Formula	C19H29N3O5S
Molecular Weight	411.52 g/mol
Synonyms	L-786,392 Intermediate; (4R,5R,6S)-6-[(1R)-1-Hydroxyethyl]-4-methyl-3-[[(3S,5S)-5-[(1R)-1-hydroxy-3-(methylamino)propyl]-3-pyrrolidinyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid; Carbapenem Intermediate L-786,392; (4R,5R,6S)-3-[(3S,5S)-5-[(1R)-1-Hydroxy-3-(methylamino)propyl]-3-pyrrolidinyl]thio-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid; Merck L-786,392 Precursor
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredient (API) starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.