Description

(2S)-2-[[(2S)-2-dimethylamino-3-methyl-butanoyl]amino]-N-[(3R,4S,5S)-3-methoxy-1-[(3R)-3-[(1R,2R)-1-methoxy-2-(phenethylcarbamoyl)propyl]pyrrolidin-1-yl]-5-methyl-1-oxo-heptan-4-yl]-N,3-dimethyl-butanamide is a sophisticated, high-purity synthetic peptide derivative designed for advanced pharmaceutical research and development. This compound is critical for its role as a key intermediate or active pharmaceutical ingredient (API) in the synthesis of complex therapeutic agents, particularly in oncology and targeted drug delivery systems. It is essential for pharmaceutical manufacturers, biotechnology firms, and advanced research institutions focused on developing next-generation peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of complex peptide-based Active Pharmaceutical Ingredients (APIs).
• Oncology Research: Used in the development and study of novel anti-cancer drugs, particularly those targeting specific cellular pathways.
• Drug Discovery & Development: A valuable compound for medicinal chemistry programs, enabling structure-activity relationship (SAR) studies and lead optimization.
• Preclinical & Clinical Trial Material: Supplied as a high-purity component for the production of materials used in non-clinical and clinical studies.
• Peptide Chemistry Research: Employed in academic and industrial laboratories to explore new peptide synthesis methodologies and conjugate formations.
• Targeted Therapy Development: Utilized in creating drug conjugates designed for specific tissue or receptor targeting to enhance efficacy and reduce side effects.

Basic Information

Product Name	(2S)-2-[[(2S)-2-dimethylamino-3-methyl-butanoyl]amino]-N-[(3R,4S,5S)-3-methoxy-1-[(3R)-3-[(1R,2R)-1-methoxy-2-(phenethylcarbamoyl)propyl]pyrrolidin-1-yl]-5-methyl-1-oxo-heptan-4-yl]-N,3-dimethyl-butanamide
CAS No.	149606-27-9
Molecular Formula	C41H69N5O7
Molecular Weight	743.99 g/mol
Synonyms	Bortezomib Intermediate; BZM Intermediate; [(1R)-2-[[(2S)-2-[[(2S)-2-(Dimethylamino)-3-methylbutanoyl]amino]-N,3-dimethylbutanoyl]-N-[(3R,4S,5S)-3-methoxy-1-[(3R)-3-[(1R,2R)-1-methoxy-2-(phenethylcarbamoyl)propyl]-1-pyrrolidinyl]-5-methyl-1-oxoheptan-4-yl]amide; PS-341 Intermediate; MLN-341 Intermediate; LDP-341 Intermediate; Velcade® Intermediate
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to stringent Good Manufacturing Practice (GMP) principles where applicable. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets exacting specifications for pharmaceutical use. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Single Maximum Impurity	≤ 0.5%
Total Impurities	≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.