Description

4-[4-(4-Methyl-Piperazin-1-Yl)-Piperidin-1-Yl]-1-Nitrobenzene is a high-purity, advanced pharmaceutical intermediate featuring a complex piperazine-piperidine scaffold linked to a nitrobenzene moiety. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities, especially within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, particularly those targeting protein kinases and G-protein-coupled receptors (GPCRs).
• Research & Development (R&D): Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in early-stage drug discovery projects.
• API Synthesis: Serves as a core scaffold for constructing final active pharmaceutical ingredients, especially in the production of potential anti-cancer and neuropharmacological agents.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development, validation, and quality control in regulatory submissions.
• Custom Synthesis Building Block: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis services for client-specific molecular targets.

Basic Information

Product Name	4-[4-(4-Methyl-Piperazin-1-Yl)-Piperidin-1-Yl]-1-Nitrobenzene
CAS No.	959795-69-8
Molecular Formula	C16H24N4O2
Molecular Weight	304.39 g/mol
Synonyms	1-Nitro-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]benzene; 4-[4-(4-Methylpiperazin-1-yl)piperidin-1-yl]-1-nitrobenzene; 1-Nitro-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]benzene; 959795-69-8; 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)nitrobenzene; 4-(4-Methylpiperazin-1-yl)-1-(4-nitrophenyl)piperidine
EINECS	Contact for details

Quality Control

Our 4-[4-(4-Methyl-Piperazin-1-Yl)-Piperidin-1-Yl]-1-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.