Description

(3S)-4-Boc-1-Carboxymethyl-3-Isobutyl-Piperazin-2-One is a high-purity, advanced pharmaceutical intermediate featuring a protected piperazinone scaffold. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors and other therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially protease inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic targets.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up API manufacturing processes.
• Peptidomimetic Synthesis: Employed in the construction of complex peptidomimetic molecules due to its chiral piperazinone core.
• Custom Synthesis: A versatile substrate for custom chemical synthesis and contract manufacturing organizations (CMOs).

Basic Information

Product Name	(3S)-4-Boc-1-Carboxymethyl-3-Isobutyl-Piperazin-2-One
CAS No.	959584-21-5
Molecular Formula	C16H28N2O5
Molecular Weight	328.41 g/mol
Synonyms	1-[(tert-Butoxycarbonyl)methyl]-4-[(2S)-2-isobutyl-3-oxopiperazin-1-yl]acetic acid; 4-[(tert-Butoxycarbonyl)methyl]-1-[(2S)-2-isobutyl-3-oxopiperazin-1-yl]acetic acid; (3S)-1-Carboxymethyl-4-(tert-butoxycarbonyl)-3-isobutylpiperazin-2-one; Boc-Pip(3-iBu)-OH; tert-Butyl (2S)-2-isobutyl-3-oxo-1-(carboxymethyl)piperazine-1-carboxylate; 959584-21-5; (3S)-4-Boc-1-Carboxymethyl-3-Isobutyl-2-Piperazinone
EINECS	Contact for details

Quality Control

Our (3S)-4-Boc-1-Carboxymethyl-3-Isobutyl-Piperazin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.