Description

1-n-Boc-4-(3-Carboxymethyl-4-Oxo-3,4-Dihydroquinazolin-6-Yl)Piperazine is a sophisticated heterocyclic building block of significant interest in advanced organic synthesis. This compound is valued for its dual functionality, incorporating both a protected piperazine amine and a quinazolinone carboxylic acid derivative, making it a versatile intermediate. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the development of novel therapeutic agents, particularly in kinase inhibitor and targeted oncology programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of small molecule drug candidates, especially those targeting protein kinases.
• Chemical Biology Probe Development: Used to create tool compounds for studying enzyme function and cellular signaling pathways.
• Peptidomimetic Synthesis: Serves as a constrained scaffold to mimic peptide structures and enhance metabolic stability in drug design.
• Library Synthesis for High-Throughput Screening: Employed in combinatorial chemistry to generate diverse compound libraries for biological activity screening.
• API (Active Pharmaceutical Ingredient) Development: Integral in the multi-step synthesis of complex active ingredients under GMP conditions.
• Academic & Contract Research: Used in university and CRO settings for fundamental research in medicinal chemistry and heterocyclic chemistry.

Basic Information

Product Name	1-n-Boc-4-(3-Carboxymethyl-4-Oxo-3,4-Dihydroquinazolin-6-Yl)Piperazine
CAS No.	959246-63-0
Molecular Formula	C20H24N4O5
Molecular Weight	400.43 g/mol
Synonyms	1-Boc-4-(3-(carboxymethyl)-4-oxo-3,4-dihydroquinazolin-6-yl)piperazine; tert-Butyl 4-(3-(carboxymethyl)-4-oxo-3,4-dihydroquinazolin-6-yl)piperazine-1-carboxylate; 6-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-3-(carboxymethyl)quinazolin-4(3H)-one; 959246-63-0; BOC-Piperazine-Quinazolinone Acid; Quinazolinone-Piperazine-BOC Carboxylic Acid
EINECS	Contact for details

Quality Control

Our 1-n-Boc-4-(3-Carboxymethyl-4-Oxo-3,4-Dihydroquinazolin-6-Yl)Piperazine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting full specifications are provided and can be tailored to meet specific project requirements, including those for research use and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.