Description

5-(tert-Butyl)-2-Bromopyrazine is a high-purity brominated pyrazine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of the bromine atom and the bulky tert-butyl group, which facilitates selective cross-coupling reactions and introduces steric hindrance for precise molecular design. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Used in the development of organic electronic materials, such as ligands for OLEDs and charge-transport molecules.
• Cross-Coupling Reactions: Essential substrate for Suzuki, Stille, and Negishi couplings to form complex biaryl and heteroaryl structures.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in homogeneous catalysis.
• Chemical Research: A versatile reagent for exploring new synthetic methodologies and constructing pyrazine-based compound libraries.

Basic Information

Product Name	5-(tert-Butyl)-2-Bromopyrazine
CAS No.	959238-69-8
Molecular Formula	C8H11BrN2
Molecular Weight	215.09 g/mol
Synonyms	2-Bromo-5-tert-butylpyrazine; 5-tert-Butyl-2-bromopyrazine; 2-Bromo-5-(1,1-dimethylethyl)pyrazine; 5-(1,1-Dimethylethyl)-2-bromopyrazine; 5-(tert-Butyl)pyrazine-2-bromide; Pyrazine, 2-bromo-5-(1,1-dimethylethyl)-; 959238-69-8
EINECS	Contact for details

Quality Control

Our 5-(tert-Butyl)-2-Bromopyrazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with stringent industry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.