Description

2-Chloro-5-Fluoropyrazine is a high-value fluorinated and chlorinated heterocyclic building block essential for modern synthetic chemistry. This compound is prized for its dual halogen functionality, which enables selective cross-coupling reactions and the introduction of structural complexity into target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the pyrazine core for bioactivity.
• Material Science Research: Serves as a precursor for the synthesis of specialized ligands, organic semiconductors, and fluorinated polymers.
• Cross-Coupling Reactions: The chlorine and fluorine atoms provide distinct reactivity for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions.
• Chemical Biology Probes: Employed in the design and synthesis of fluorinated probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	2-Chloro-5-Fluoropyrazine
CAS No.	959019-05-7
Molecular Formula	C4H2ClFN2
Molecular Weight	132.52 g/mol
Synonyms	5-Fluoro-2-chloropyrazine; 2-Chloro-5-fluoropyrazine; 2-Chloro-5-fluoro-1,4-diazine; 5-Fluoro-2-chloro-1,4-diazine; Fluorochloropyrazine; Pyrazine, 2-chloro-5-fluoro-; 959019-05-7
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoropyrazine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.