Description

(2S,6R)-1,2,6-Trimethylpiperazine2,2,2-Trifluoroacetate is a high-purity chiral piperazine derivative, serving as a critical building block in advanced pharmaceutical synthesis. Its defined stereochemistry and trifluoroacetate salt form make it an essential intermediate for developing active pharmaceutical ingredients (APIs) with specific biological activity. This compound is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in the areas of central nervous system (CNS) agents and complex small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized as a stereochemically defined building block for constructing molecules with specific three-dimensional configurations.
• Medicinal Chemistry Research: Serves as a versatile scaffold in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Ligand and Catalyst Precursor: Potential use in the preparation of chiral ligands or organocatalysts for enantioselective transformations.

Basic Information

Product Name	(2S,6R)-1,2,6-Trimethylpiperazine2,2,2-Trifluoroacetate
CAS No.	958030-45-0
Molecular Formula	C9H17F3N2O2
Molecular Weight	242.24 g/mol
Synonyms	(2S,6R)-1,2,6-Trimethylpiperazine Trifluoroacetate Salt; (2S,6R)-1,2,6-Trimethylpiperazine TFA Salt; (2S,6R)-1,2,6-Trimethylpiperazine 2,2,2-Trifluoroacetate; 1,2,6-Trimethylpiperazine (2S,6R)-isomer trifluoroacetate; (2S,6R)-TMP TFA Salt; (2S,6R)-1,2,6-Trimethylpiperazine; 2,2,2-Trifluoroacetic Acid Salt
EINECS	Contact for details

Quality Control

Our (2S,6R)-1,2,6-Trimethylpiperazine2,2,2-Trifluoroacetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes rigorous analytical testing, including chiral purity verification, to meet the exacting standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.