Description

(S)-2-Fluoro-4-Methylpentanoic Acid is a high-purity, single-enantiomer chiral building block featuring a fluorine atom at the alpha position of a branched carboxylic acid. This specific stereochemistry and functional group combination make it a valuable intermediate for the synthesis of complex molecules where chirality and fluorine substitution are critical for biological activity and metabolic stability. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, including potential protease inhibitors and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in protease inhibitor programs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides where the fluorine atom enhances lipophilicity and biological activity.
• Peptidomimetics & Bioisosteres: Serves as a fluorine-containing amino acid analog for designing peptide mimics with improved stability and binding affinity.
• Ligand & Catalyst Development: Employed in the synthesis of chiral ligands and organocatalysts for asymmetric synthesis applications.
• Material Science Research: Investigated as a monomer or modifier for introducing fluorine into specialty polymers to alter surface properties.
• Fluorine Chemistry Studies: A valuable reference compound and building block in academic and industrial research focused on stereoselective fluorination reactions.

Basic Information

Product Name	(S)-2-Fluoro-4-Methylpentanoic Acid
CAS No.	956931-72-9
Molecular Formula	C6H11FO2
Molecular Weight	134.15 g/mol
Synonyms	(S)-2-Fluoro-4-methylvaleric acid; (2S)-2-Fluoro-4-methylpentanoic acid; L-2-Fluoro-4-methylpentanoic acid; (S)-α-Fluoro-4-methylvaleric acid; 4-Methyl-2-fluoropentanoic acid, (S)-; 956931-72-9; Pentanoic acid, 2-fluoro-4-methyl-, (2S)-
EINECS	Contact for details

Quality Control

Every batch of (S)-2-Fluoro-4-Methylpentanoic Acid is produced and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and enantiomeric excess meet the exacting standards required for advanced synthetic applications. A Certificate of Analysis (COA) detailing specifications such as assay (by HPLC/NMR), enantiomeric purity (by Chiral HPLC), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Enantiomeric Excess (Chiral HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.