Description

4-(2-Hydroxymethyl-4-Nitro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core with a nitro-substituted aromatic ring and a tert-butyloxycarbonyl (Boc) protecting group. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and other therapeutic agents. It is primarily utilized by pharmaceutical R&D departments, contract manufacturing organizations (CMOs), and fine chemical suppliers engaged in custom synthesis and process development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting neurological pathways.
• API Synthesis: Used in multi-step synthetic routes for constructing complex molecules with piperazine pharmacophores.
• Chemical Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Custom Synthesis: Supplied for the preparation of proprietary compounds and reference standards.
• Academic Research: Used in university and institutional labs for studying organic reaction mechanisms and developing new synthetic methodologies.

Basic Information

Product Name	4-(2-Hydroxymethyl-4-Nitro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	955369-05-8
Molecular Formula	C17H25N3O5
Molecular Weight	351.40 g/mol
Synonyms	4-(2-Hydroxymethyl-4-nitrophenyl)piperazine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(2-(hydroxymethyl)-4-nitrophenyl)piperazine-1-carboxylate; 1-Boc-4-(2-hydroxymethyl-4-nitrophenyl)piperazine; 4-(2-Hydroxymethyl-4-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester; 955369-05-8; 4-(2-Hydroxymethyl-4-nitro-phenyl)piperazine-1-carboxylic acid tert-butyl ester; Boc-4-(2-Hydroxymethyl-4-nitrophenyl)piperazine
EINECS	Contact for details

Quality Control

Our production of 4-(2-Hydroxymethyl-4-Nitro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.