Description

2-Bromo-5-(4-Methylpiperazin-1-Yl)Pyrazine is a high-purity, advanced pharmaceutical intermediate characterized by its bromopyrazine core functionalized with a methylpiperazine moiety. This compound is of significant value for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research and development. It is primarily sought after by pharmaceutical R&D laboratories, contract research/manufacturing organizations (CROs/CMOs), and fine chemical suppliers serving the global life sciences sector.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted therapeutic agents, especially kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to develop novel drug candidates.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds to study specific biological pathways and protein functions.
• Custom Synthesis: Employed by CROs and CDMOs for the contract manufacturing of proprietary compounds and development compounds under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	2-Bromo-5-(4-Methylpiperazin-1-Yl)Pyrazine
CAS No.	955050-06-3
Molecular Formula	C9H13BrN4
Molecular Weight	257.13 g/mol
Synonyms	2-Bromo-5-(4-methyl-1-piperazinyl)pyrazine; 5-Bromo-2-(4-methylpiperazin-1-yl)pyrazine; 2-(4-Methylpiperazin-1-yl)-5-bromopyrazine; Pyrazine, 2-bromo-5-(4-methyl-1-piperazinyl)-; 955050-06-3
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-(4-Methylpiperazin-1-Yl)Pyrazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.