Description

cis-Methyl-4-Hydroxypiperidine-2-Carboxylate Hydrochloride is a high-purity, pharmaceutically relevant chiral building block and synthetic intermediate. This compound is of significant value for its role in constructing complex molecular architectures, particularly in the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for process development and scale-up.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly those targeting the central nervous system (CNS).
• API Building Block: Used in the construction of complex piperidine-based pharmacophores for various therapeutic areas.
• Asymmetric Synthesis: Serves as a valuable starting material or intermediate in stereoselective chemical transformations.
• Agrochemical Research: Employed in the development of new pesticides and herbicides with specific chiral activity.
• Chemical Biology: Used as a probe or scaffold in medicinal chemistry and biochemical research.
• Custom Synthesis: A critical component for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical services.

Basic Information

Product Name	cis-Methyl-4-Hydroxypiperidine-2-Carboxylate Hydrochloride
CAS No.	955027-91-5
Molecular Formula	C8H15NO3 • HCl
Molecular Weight	209.67 g/mol (Free base: 173.21 g/mol)
Synonyms	Methyl (3R,4R)-4-hydroxypiperidine-3-carboxylate hydrochloride; (3R,4R)-Methyl 4-hydroxypiperidine-3-carboxylate HCl; cis-4-Hydroxy-3-piperidinecarboxylic acid methyl ester hydrochloride; Methyl cis-4-hydroxypiperidine-3-carboxylate hydrochloride; 3-Piperidinecarboxylic acid, 4-hydroxy-, methyl ester, hydrochloride, (3R,4R)-; cis-3-(Methoxycarbonyl)-4-hydroxypiperidine hydrochloride
EINECS	Contact for details

Quality Control

Our cis-Methyl-4-Hydroxypiperidine-2-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.