Description

Propanoic Acid, 2,2-Dimethyl-, 4-[(4-Fluoro-2-Methyl-1H-Indol-5-Yl)Oxy]-5-Methylpyrrolo[2,1-F][1,2,4]Triazin-6-Yl Ester is a high-purity, complex heterocyclic ester designed for advanced pharmaceutical research and development. This compound serves as a critical advanced intermediate or active pharmaceutical ingredient (API) in the synthesis of targeted therapeutics. It is essential for organizations engaged in oncology drug discovery, kinase inhibitor development, and preclinical studies, where precise molecular structure and reliable purity are paramount for successful outcomes.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, particularly in oncology.
• Kinase Inhibitor Research: Used in the development and screening of potent, selective kinase inhibitors due to its specific indole and triazine-based structure.
• Preclinical Drug Development: Serves as a reference standard or starting material for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Chemical Biology Probes: Utilized in creating molecular probes to study specific enzyme functions and cellular signaling pathways.
• Process Chemistry & Scale-Up: Supports route scouting, optimization, and pilot-scale manufacturing for new chemical entities (NCEs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global pharmaceutical innovation pipelines.

Basic Information

Product Name	Propanoic Acid, 2,2-Dimethyl-, 4-[(4-Fluoro-2-Methyl-1H-Indol-5-Yl)Oxy]-5-Methylpyrrolo[2,1-F][1,2,4]Triazin-6-Yl Ester
CAS No.	952490-01-6
Molecular Formula	C22H22FN5O3
Molecular Weight	423.44 g/mol
Synonyms	4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl 2,2-dimethylpropanoate; Pivalic acid, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl ester; 952490-01-6; 5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-ol, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-, 2,2-dimethylpropanoate; Complex Indole-Triazine Ester; Fluorinated Indolylpyrrolotriazine Ester
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and traceability. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.