Description

tert-Butyl 4-[(2-Fluoro-4-Nitrophenyl)Amino]Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine core and functionalized aromatic ring. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities and fine chemical production.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and other specialized therapeutic areas.
• Organic Synthesis Research: Serves as a versatile precursor for medicinal chemistry research, enabling the exploration of structure-activity relationships (SAR).
• API Development: Used in the development and scale-up processes for new Active Pharmaceutical Ingredients (APIs) requiring a fluorinated aniline-piperidine motif.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development and quality control in pharmaceutical laboratories.
• Custom Synthesis: A starting material for the custom synthesis of more complex, proprietary molecules for preclinical and clinical studies.

Basic Information

Product Name	tert-Butyl 4-[(2-Fluoro-4-Nitrophenyl)Amino]Piperidine-1-Carboxylate
CAS No.	952285-81-3
Molecular Formula	C16H22FN3O4
Molecular Weight	339.37 g/mol
Synonyms	1-Boc-4-[(2-Fluoro-4-nitrophenyl)amino]piperidine; 4-[(2-Fluoro-4-nitrophenyl)amino]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-((2-fluoro-4-nitrophenyl)amino)piperidine-1-carboxylate; N-(2-Fluoro-4-nitrophenyl)-N-(1-Boc-piperidin-4-yl)amine; 1,1-Dimethylethyl 4-[(2-fluoro-4-nitrophenyl)amino]-1-piperidinecarboxylate; 4-[(2-Fluoro-4-nitrophenyl)amino]piperidine-1-carboxylic acid tert-butyl ester; 952285-81-3; Boc-4-[(2-Fluoro-4-nitrophenyl)amino]piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-[(2-Fluoro-4-Nitrophenyl)Amino]Piperidine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.