Description

1,6-Naphthyridin-4(1H)-One, 7-Chloro- CAS NO 952138-12-4 is a high-purity heterocyclic organic compound belonging to the naphthyridine class, serving as a critical advanced pharmaceutical intermediate. Its value lies in its role as a sophisticated building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. This product is essential for research institutions and pharmaceutical manufacturers engaged in drug discovery and development, especially for projects targeting kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Kinase Inhibitor Development: Core scaffold for research and production of potential kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization to create diverse chemical libraries for high-throughput screening.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-scale production of clinical trial materials.

Basic Information

Product Name	1,6-Naphthyridin-4(1H)-One, 7-Chloro-
CAS No.	952138-12-4
Molecular Formula	C8H5ClN2O
Molecular Weight	180.59 g/mol
Synonyms	7-Chloro-1,6-naphthyridin-4(1H)-one; 7-Chloro-1H-1,6-naphthyridin-4-one; 7-Chloro-1,6-naphthyridin-4-ol; 7-Chloro-4-hydroxy-1,6-naphthyridine; 952138-12-4; 7-Chloro-1,6-naphthyridin-4-one; 7-Chloro-4(1H)-1,6-naphthyridinone
EINECS	Contact for details

Quality Control

Our 1,6-Naphthyridin-4(1H)-One, 7-Chloro- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development projects requiring material for pre-clinical and clinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is light-sensitive (store away from light). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.