Description

4-Hydroxy-Bicyclo[2.2.2]Octane-1-Carboxylic Acid is a high-purity, functionalized bicyclic carboxylic acid derivative valued for its rigid, three-dimensional structure and reactive hydroxyl and carboxyl groups. This compound serves as a critical chiral building block and advanced intermediate in sophisticated organic synthesis, enabling the construction of complex molecular architectures. It is essential for research and development in the pharmaceutical, agrochemical, and specialty chemical industries, where precise molecular geometry and functional group compatibility are paramount.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs requiring rigid, chiral scaffolds to enhance binding affinity and metabolic stability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators that leverage its unique bicyclic framework.
• Ligand and Catalyst Development: Serves as a backbone for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Building block for novel polymers, dendrimers, and supramolecular structures where its defined geometry controls material properties.
• Fine Chemical Production: Intermediate for manufacturing specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	4-Hydroxy-Bicyclo[2.2.2]Octane-1-Carboxylic Acid
CAS No.	1127-13-5
Molecular Formula	C9H14O3
Molecular Weight	170.21 g/mol
Synonyms	4-Hydroxybicyclo[2.2.2]octane-1-carboxylic acid; 1-Carboxy-4-hydroxybicyclo[2.2.2]octane; 4-Hydroxy-1-bicyclo[2.2.2]octanecarboxylic acid; Bicyclo[2.2.2]octane-1-carboxylic acid, 4-hydroxy-; 4-Hydroxy-BCO-1-carboxylic acid; 4-OH-BCO-1-COOH; 1-Bicyclo[2.2.2]octanecarboxylic acid, 4-hydroxy-
EINECS	214-426-8

Quality Control

Our 4-Hydroxy-Bicyclo[2.2.2]Octane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.