Description

1-[2-(Methylsulfonyl)Phenyl]Piperidine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine carboxylic acid core and methylsulfonylphenyl substituent. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily utilized by pharmaceutical R&D departments, fine chemical manufacturers, and contract research organizations (CROs) engaged in modern drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of new drug candidates, especially in neurological and psychiatric therapeutic areas.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) requiring a functionalized piperidine scaffold.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale production for new chemical entities (NCEs).
• Biochemical Tool Compound: May be used in the development of biochemical probes and assay reagents for target validation.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke synthesis services.

Basic Information

Product Name	1-[2-(Methylsulfonyl)Phenyl]Piperidine-3-Carboxylic Acid
CAS No.	951625-03-9
Molecular Formula	C14H17NO4S
Molecular Weight	295.35 g/mol
Synonyms	1-(2-Methanesulfonylphenyl)piperidine-3-carboxylic acid; 3-Piperidinecarboxylic acid, 1-[2-(methylsulfonyl)phenyl]-; 1-(2-Methylsulfonylphenyl)piperidine-3-carboxylic acid; 1-(2-(Methylsulfonyl)phenyl)piperidine-3-carboxylic acid; 951625-03-9; UNII-9G9N8S2F1T; 9G9N8S2F1T; 1-[2-(Methylsulfonyl)phenyl]-3-piperidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our production of 1-[2-(Methylsulfonyl)Phenyl]Piperidine-3-Carboxylic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all critical quality attributes to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.