Description

Jnj-38158471 is a high-purity, research-grade small-molecule compound developed as a selective inhibitor targeting specific kinase pathways in preclinical oncology and immunology studies. It serves as a critical tool for mechanism-of-action validation, target engagement assessment, and lead optimization in drug discovery programs. Pharmaceutical R&D teams, contract research organizations (CROs), and academic translational labs rely on its consistent batch-to-batch performance for reliable in vitro and in vivo pharmacological profiling.

Application

• Preclinical target validation in hematologic malignancy models (e.g., AML, CLL)
• Lead optimization support for next-generation kinase inhibitors
• In vitro cellular assays measuring phospho-protein inhibition (e.g., p-ERK, p-AKT)
• Co-crystallization studies for structural biology and binding mode analysis
• Reference standard in LC-MS/MS bioanalytical method development
• Control compound in selectivity profiling panels (kinase strip assays)
• Pharmacokinetic and metabolism studies (ADME) in rodent models
• Stability-indicating assay development for related API candidates

Basic Information

Product Name	Jnj-38158471
CAS No.	951151-97-6
Molecular Formula	C₂₃H₂₅N₇O₂
Molecular Weight	431.49 g/mol
Synonyms	JNJ-38158471; JNJ 38158471; N-(4-((2R,4S)-2-((S)-2-Amino-3-methylbutanoyl)-4-(4-cyanophenyl)-1-piperazinyl)-3-fluorophenyl)-2-(methylsulfonyl)benzamide; JNJ38158471; JNJ-38158471 hydrochloride (common salt form); UNII-7Q6T7X7Z1F; CHEMBL2177120; Z2177120
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches meet stringent criteria for identity, purity (>99.0% by HPLC), residual solvents (ICH Q3C compliant), heavy metals (<10 ppm), and microbiological limits (where applicable). Testing follows validated methods aligned with USP & EP guidelines, and manufacturing adheres to ISO 9001-certified quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8°C under inert atmosphere (argon or nitrogen) to prevent oxidation. Keep desiccated; avoid exposure to ambient humidity. Handle in a well-ventilated area away from strong acids, organic solvents, fluorides, and strong alkalis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥99.0%
Related Substances (HPLC)	Single impurity ≤0.3%; Total impurities ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Water Content (KF)	≤0.5%
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.