Description

2-(Piperidin-4-Yloxy)Pyrazine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 950649-21-5. This compound is valued for its role as a critical building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry research and development. It is primarily sought by pharmaceutical companies and contract research organizations (CROs) engaged in the discovery and scale-up of new therapeutic agents, especially within central nervous system (CNS) and oncology drug pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize lead compounds.
• API Development: Serves as a building block in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Utilized in the development of specialized probes for studying enzyme function and receptor interactions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and process development projects.
• Academic Research: Employed in university and institutional labs for foundational research in heterocyclic and medicinal chemistry.

Basic Information

Product Name	2-(Piperidin-4-Yloxy)Pyrazine Dihydrochloride
CAS No.	950649-21-5
Molecular Formula	C9H14Cl2N3O
Molecular Weight	251.13 g/mol
Synonyms	2-[(Piperidin-4-yl)oxy]pyrazine dihydrochloride; 2-(4-Piperidyloxy)pyrazine dihydrochloride; 2-(Piperidin-4-yloxy)pyrazine hydrochloride (1:2); Pyrazine, 2-(4-piperidinyloxy)-, dihydrochloride; 950649-21-5; UNII-3K1N3J7Q2S; 3K1N3J7Q2S
EINECS	Contact for details

Quality Control

Our 2-(Piperidin-4-Yloxy)Pyrazine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.