Description

Methyl 3-Fluoro-4-(4-Methyl-1-Piperazinyl)Benzoate CAS NO 948018-58-4 is a high-purity, advanced pharmaceutical intermediate characterized by its benzoate ester core substituted with a fluorine atom and a methylpiperazine moiety. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of targeted drug candidates with enhanced pharmacokinetic properties. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly within the central nervous system (CNS) and oncology research sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for receptor-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• CNS Drug Development: Serves as a building block for potential antipsychotic, antidepressant, or neuroprotective agents due to the piperazine pharmacophore.
• Oncology Research: Employed in the synthesis of small-molecule inhibitors targeting specific kinases or other cancer-related pathways.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological mechanisms and protein function.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	Methyl 3-Fluoro-4-(4-Methyl-1-Piperazinyl)Benzoate
CAS No.	948018-58-4
Molecular Formula	C13H17FN2O2
Molecular Weight	252.29 g/mol
Synonyms	3-Fluoro-4-(4-methylpiperazin-1-yl)benzoic acid methyl ester; Methyl 3-fluoro-4-(4-methylpiperazin-1-yl)benzoate; Benzoic acid, 3-fluoro-4-(4-methyl-1-piperazinyl)-, methyl ester; 948018-58-4; 3-Fluoro-4-(N-methylpiperazino)methyl benzoate
EINECS	Contact for details

Quality Control

Our Methyl 3-Fluoro-4-(4-Methyl-1-Piperazinyl)Benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with complete batch data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.