Description

(R)-tert-Butyl 2-(2-Hydroxyethyl)Piperazine-1-Carboxylate-Hcl is a high-purity chiral piperazine derivative and a key protected intermediate in advanced organic synthesis. Its value lies in providing a stereochemically defined building block for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for process development and scale-up.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• API Synthesis: Used in the construction of complex molecular scaffolds for active pharmaceutical ingredients, leveraging its piperazine core and protected amine functionality.
• Agrochemical Research: Serves as a building block for developing new generation pesticides and herbicides with specific chiral activity.
• Ligand and Catalyst Preparation: Utilized in the preparation of chiral ligands for asymmetric catalysis and metal complexes.
• Peptidomimetics: Incorporated into the design and synthesis of peptidomimetic compounds for biomedical research.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	(R)-tert-Butyl 2-(2-Hydroxyethyl)Piperazine-1-Carboxylate Hydrochloride
CAS No.	947275-74-3
Molecular Formula	C11H23ClN2O3
Molecular Weight	266.77 g/mol
Synonyms	(R)-1-Boc-2-(2-Hydroxyethyl)piperazine hydrochloride; tert-Butyl (R)-2-(2-hydroxyethyl)piperazine-1-carboxylate hydrochloride; (R)-1-N-Boc-2-(2-Hydroxyethyl)piperazine HCl; Boc-HEP-HCl (R-enantiomer); (R)-2-(2-Hydroxyethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester hydrochloride; (R)-N-Boc-2-(2-Hydroxyethyl)piperazine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 2-(2-Hydroxyethyl)Piperazine-1-Carboxylate-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.