Description

(S)-1-Boc-4-Benzyl-2-(Hydroxymethyl)Piperazine is a high-value, chiral piperazine derivative that serves as a critical building block in modern organic synthesis. Its primary value lies in its role as a sophisticated intermediate for constructing complex molecules, particularly in the pharmaceutical sector. This compound is essential for research and development chemists and process scale-up teams working on active pharmaceutical ingredients (APIs), especially those targeting neurological and oncological pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Peptidomimetic Chemistry: Used to introduce constrained piperazine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme function and receptor interactions.
• Custom Synthesis & Contract Manufacturing: A requested intermediate for custom synthesis projects at CROs and CDMOs serving the global pharmaceutical market.

Basic Information

Product Name	(S)-1-Boc-4-Benzyl-2-(Hydroxymethyl)Piperazine
CAS No.	947275-34-5
Molecular Formula	C17H26N2O3
Molecular Weight	306.40 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)-4-benzyl-2-(hydroxymethyl)piperazine; (S)-N-Boc-4-Benzyl-2-piperazinemethanol; (S)-1-Boc-4-Benzylpiperazine-2-methanol; tert-Butyl (S)-4-benzyl-2-(hydroxymethyl)piperazine-1-carboxylate; (2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-4-benzyl-2-(hydroxymethyl)piperazine; (S)-1-Boc-4-Bn-2-HMP; BOC-Bn-Pip(2-CH2OH)-OH
EINECS	Contact for details

Quality Control

Our (S)-1-Boc-4-Benzyl-2-(Hydroxymethyl)Piperazine is manufactured under strict quality management systems. Each batch is analyzed to ensure high chiral purity and chemical integrity, with specifications typically meeting or exceeding 98.0% purity (HPLC). Comprehensive testing includes identity confirmation, assay, chiral purity by chiral HPLC, and control of residual solvents. Certificates of Analysis (COA) documenting full compliance are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.