Description

5-Bromo-3-(2,2,2-trifluoroethoxy)pyrazin-2-amine is a specialized heterocyclic building block featuring a bromo-substituted pyrazine core with a trifluoroethoxy side chain. This compound is valued for its unique molecular architecture, which combines halogen and fluorine functionalities to modulate electronic properties and metabolic stability in target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and pesticides where the fluorine moiety enhances biological activity and environmental persistence.
• Chemical Biology Probe Development: Serves as a versatile scaffold for constructing molecular probes to study enzyme function and biological pathways.
• Material Science Research: Investigated as a precursor for organic electronic materials and liquid crystals due to its electron-deficient aromatic system.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring high-purity advanced intermediates.

Basic Information

Product Name	5-Bromo-3-(2,2,2-trifluoroethoxy)pyrazin-2-amine
CAS No.	947249-22-1
Molecular Formula	C6H5BrF3N3O
Molecular Weight	272.02 g/mol
Synonyms	2-Amino-5-bromo-3-(2,2,2-trifluoroethoxy)pyrazine; 5-Bromo-3-(2,2,2-trifluoroethoxy)-2-pyrazinamine; 947249-22-1; 5-Bromo-3-(2,2,2-trifluoroethoxy)pyrazin-2-ylamine; 2-Pyrazinamine, 5-bromo-3-(2,2,2-trifluoroethoxy)-; AKOS025247315; BRN 12516151
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-(2,2,2-trifluoroethoxy)pyrazin-2-amine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.