Description

3-(2-Chloro-5-Fluorophenoxy)Piperidine is a high-purity, advanced pharmaceutical intermediate characterized by its unique piperidine-phenoxy ether structure. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug discovery programs. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to ensure the structural integrity and efficacy of their final drug candidates, relying on its consistent quality for scalable and reproducible synthesis.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in CNS-targeted therapies.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, leveraging its halogenated phenoxy moiety.
• Ligand & Catalyst Development: Serves as a precursor or framework for creating specialized ligands in asymmetric catalysis.
• Material Science: Investigated as a monomer or additive for synthesizing specialty polymers with specific thermal or optical properties.
• Academic & Contract Research: Employed in medicinal chemistry and organic synthesis research within universities and CROs (Contract Research Organizations).
• Process Chemistry: Utilized in route scouting and optimization for the commercial-scale production of complex molecules.

Basic Information

Product Name	3-(2-Chloro-5-Fluorophenoxy)Piperidine
CAS No.	946759-52-0
Molecular Formula	C11H13ClFNO
Molecular Weight	229.68 g/mol
Synonyms	3-[(2-Chloro-5-fluorophenoxy)]piperidine; Piperidine, 3-[(2-chloro-5-fluorophenoxy)]-; 2-Chloro-5-fluoro-3-piperidinyloxybenzene; 3-(2-Chloro-5-fluorophenoxy)piperidine; 946759-52-0; 3-(2-Chloro-5-fluoro-phenoxy)-piperidine
EINECS	Contact for details

Quality Control

Our 3-(2-Chloro-5-Fluorophenoxy)Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles where applicable, supporting our customers' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.