Description

Velagliflozin is a high-purity, selective sodium-glucose cotransporter 2 (SGLT2) inhibitor used as a key pharmaceutical intermediate. This compound is critical for the research and development of next-generation antidiabetic therapeutics targeting improved glycemic control. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and API producers engaged in metabolic disease drug development.

Application

• Primary use as a pharmaceutical reference standard for analytical method development and validation.
• Critical active pharmaceutical ingredient (API) intermediate in the synthesis of SGLT2 inhibitor class drugs.
• Used in preclinical and clinical research to study pharmacokinetics, pharmacodynamics, and mechanism of action.
• Essential material for formulation development studies for oral solid dosage forms.
• Serves as a building block in process chemistry for route scouting and optimization.
• Utilized in impurity profiling and stability-indicating assay development.

Basic Information

Product Name	Velagliflozin
CAS No.	946525-65-1
Molecular Formula	C23H30ClN3O6
Molecular Weight	479.96 g/mol
Synonyms	(1S)-1,5-Anhydro-1-C-[4-ethyl-5-(4-fluorophenyl)-2-methyl-1-[[(4-methylphenyl)sulfonyl]methyl]-1H-pyrrol-3-yl]-D-glucitol; (1S)-1,5-Anhydro-1-C-[4-ethyl-5-(4-fluorophenyl)-2-methyl-1-[[(4-methylphenyl)sulfonyl]methyl]-1H-pyrrol-3-yl]-D-glucitol; SGLT2 Inhibitor VG; BI 10773 Impurity; BI-10773 Impurity; Empagliflozin Related Compound; Velagliflozin (BI 10773)
EINECS	Contact for details

Quality Control

Our Velagliflozin is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral purity determination, and residual solvent analysis, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) with full traceability are provided, and the material is suitable for use under cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%; Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.