Description

Phenformin CAS NO 114-86-3 is a biguanide derivative historically used as an oral antihyperglycemic agent. Its primary mechanism of action involves decreasing hepatic glucose production and improving insulin sensitivity in peripheral tissues. This compound is of significant interest in biochemical and pharmaceutical research, particularly in studies related to diabetes, metabolic pathways, and cellular energy regulation. Researchers and developers in the pharmaceutical, life sciences, and fine chemical synthesis sectors utilize it as a critical reference standard and intermediate.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for quality control and analytical method development in drug testing laboratories.
• Biochemical Research: Used in metabolic studies to investigate insulin resistance, glucose metabolism, and mitochondrial function.
• Active Pharmaceutical Ingredient (API) Intermediate: Acts as a key synthetic precursor in the development and production of antidiabetic agents.
• Academic & Clinical Research: Employed in university and institutional research projects focusing on endocrinology and pharmacology.
• Metabolic Pathway Analysis: A tool for studying the AMP-activated protein kinase (AMPK) pathway and its role in cellular energy homeostasis.

Basic Information

Product Name	Phenformin
CAS No.	114-86-3
Molecular Formula	C10H15N5
Molecular Weight	205.26 g/mol
Synonyms	Phenethylbiguanide; 1-Phenethylbiguanide; Phenformin Hydrochloride (salt form); DBI; Fenformin; INS-1; NSC-73713; N-Phenethylbiguanide
EINECS	204-052-5

Quality Control

Our Phenformin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via advanced techniques like HPLC and spectroscopy. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.