Description

Retatrutide is a novel, investigational peptide-based therapeutic agent with a unique triple agonist mechanism of action targeting the GLP-1, GIP, and glucagon receptors. This compound represents a significant advancement in metabolic disease research, offering a promising new approach for the treatment of conditions like obesity and type 2 diabetes. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and academic institutions engaged in cutting-edge metabolic and endocrine research.

Application

• Pharmaceutical Research & Development: As a key active pharmaceutical ingredient (API) or reference standard in preclinical and clinical studies for metabolic disorders.
• Obesity Therapeutics: Investigation as a potent anti-obesity agent due to its multi-hormone receptor activity promoting weight loss.
• Type 2 Diabetes Management: Research into next-generation treatments aimed at improving glycemic control and insulin sensitivity.
• Mechanistic Studies: Used in biochemical and pharmacological assays to study the pathways of GLP-1, GIP, and glucagon receptor signaling.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Formulation Development: For stability testing and the development of novel drug delivery systems for peptide therapeutics.

Basic Information

Product Name	Retatrutide
CAS No.	2381089-83-2
Molecular Formula	C172H265N45O51
Molecular Weight	~3788.2 g/mol
Synonyms	LY3437943; GGG Tri-Agonist; GLP-1/GIP/Glucagon Receptor Triple Agonist; Retatrutide (LY3437943); Tirzepatide analog; Triple incretin agonist; Anti-obesity peptide
EINECS	Contact for details

Quality Control

Our Retatrutide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, MS for identity confirmation, and tests for related substances and residual solvents. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep containers sealed under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	5.0% - 12.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.