Description

1-Piperazinecarboxylic Acid, 4-[3-(Trifluoromethyl)-2-Pyridinyl]-, 1,1-Dimethylethyl Ester is a high-value, advanced pharmaceutical intermediate characterized by its piperazine and trifluoromethylpyridine moieties. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular design. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing next-generation small molecule drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the development of advanced herbicides and pesticides, leveraging the biological activity of the trifluoromethylpyridine group.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes and tool compounds to study biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic & Industrial R&D: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	1-Piperazinecarboxylic Acid, 4-[3-(Trifluoromethyl)-2-Pyridinyl]-, 1,1-Dimethylethyl Ester
CAS No.	946399-62-8
Molecular Formula	C15H18F3N3O2
Molecular Weight	329.32 g/mol
Synonyms	tert-Butyl 4-[3-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxylate; 4-[3-(Trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; BOC-Piperazine-Trifluoromethylpyridine Derivative; 2-(4-Boc-piperazin-1-yl)-3-(trifluoromethyl)pyridine; N-Boc-4-(3-trifluoromethyl-2-pyridyl)piperazine; 946399-62-8; CAS 946399-62-8
EINECS	Contact for details

Quality Control

Our production of 1-Piperazinecarboxylic Acid, 4-[3-(Trifluoromethyl)-2-Pyridinyl]-, 1,1-Dimethylethyl Ester adheres to stringent quality management systems, ensuring batch-to-batch consistency for critical R&D and manufacturing applications. We offer material produced under cGMP-compliant conditions suitable for pharmaceutical development. All batches are supported by comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality commitment includes traceability and compliance with REACH regulations for the global market.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.