Description

4-(2-Oxo-Ethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate, enabling the controlled introduction of functionalized piperazine scaffolds into complex target molecules. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, especially for central nervous system (CNS) agents, antivirals, and kinase inhibitors.
• Peptide Mimetics & PROTACs: Used in the construction of peptide-like structures and Proteolysis Targeting Chimeras (PROTACs) due to its reactive ketone and protected amine functionalities.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Research: Employed in the synthesis of advanced crop protection agents and herbicides that utilize piperazine chemistry.
• Material Science: Acts as a monomer or cross-linking agent in the development of specialty polymers and functional materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	4-(2-Oxo-Ethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	945953-41-3
Molecular Formula	C11H20N2O3
Molecular Weight	228.29 g/mol
Synonyms	1-Boc-4-(2-oxoethyl)piperazine; tert-Butyl 4-(2-oxoethyl)piperazine-1-carboxylate; 4-(2-Oxoethyl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(2-oxoethyl)piperazine; N-Boc-4-(2-oxoethyl)piperazine; Piperazine-1-carboxylic acid, 4-(2-oxoethyl)-, 1,1-dimethylethyl ester; Boc-4-(2-oxoethyl)piperazine
EINECS	Contact for details

Quality Control

Our 4-(2-Oxo-Ethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.