Description

tert-Butyl 4-[(6-Chloro-9H-Purin-9-yl)methyl]piperidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a purine core with a piperidine-boc protecting group. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of targeted small molecule therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel drug candidates, especially in oncology and antiviral fields.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of adenosine receptor antagonists and other purine-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Kinase Inhibitor Development: Serves as a core scaffold for the development of protein kinase inhibitors targeting various disease pathways.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of complex molecules for clients.
• Chemical Biology Probes: Used to create chemical probes for studying biological processes and target validation in cellular assays.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and bioorganic chemistry.

Basic Information

Product Name	tert-Butyl 4-[(6-Chloro-9H-Purin-9-yl)methyl]piperidine-1-carboxylate
CAS No.	945896-19-5
Molecular Formula	C16H20ClN5O2
Molecular Weight	349.81 g/mol
Synonyms	1-Boc-4-((6-chloro-9H-purin-9-yl)methyl)piperidine; 1-(tert-Butoxycarbonyl)-4-((6-chloropurin-9-yl)methyl)piperidine; 4-((6-Chloro-9H-purin-9-yl)methyl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-((6-chloro-9H-purin-9-yl)methyl)piperidine-1-carboxylate; 945896-19-5; 6-Chloro-9-(1-Boc-piperidin-4-ylmethyl)-9H-purine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-[(6-Chloro-9H-Purin-9-yl)methyl]piperidine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring material traceability and reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.