Description

1-Boc-4-(4-Chloro-2-Fluorophenyl)Piperazine is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the efficient and selective construction of complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working in the pharmaceutical, agrochemical, and fine chemical industries to create novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the 4-chloro-2-fluorophenyl piperazine pharmacophore.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the bespoke production of novel chemical entities (NCEs).
• Agrochemical Development: Serves as a building block for creating new crop protection agents and herbicides.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation.
• Scale-up Process Development: Acts as a standardized intermediate for optimizing robust and scalable synthetic routes in pilot plants and manufacturing.

Basic Information

Product Name	1-Boc-4-(4-Chloro-2-Fluorophenyl)Piperazine
CAS No.	945422-81-1
Molecular Formula	C15H20ClFN2O2
Molecular Weight	314.79 g/mol
Synonyms	tert-Butyl 4-(4-chloro-2-fluorophenyl)piperazine-1-carboxylate; 1-Boc-4-(4-Chloro-2-fluorophenyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(4-chloro-2-fluorophenyl)piperazine; N-Boc-4-(4-Chloro-2-fluorophenyl)piperazine; 4-(4-Chloro-2-fluorophenyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 945422-81-1; BOC-4-(4-Chloro-2-Fluorophenyl)Piperazine
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(4-Chloro-2-Fluorophenyl)Piperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). Keep container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.