Description

2-[4-(3-Methoxyphenyl)Piperazin-1-Yl]-5-Nitrobenzonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its distinct piperazine and benzonitrile core structure. This compound is of significant value in medicinal chemistry research and development, particularly for the synthesis of novel bioactive molecules targeting the central nervous system. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for creating potential drug candidates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential antipsychotic, antidepressant, or anxiolytic drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs targeting serotonin and dopamine receptors.
• Biochemical Tool Compound: Serves as a reference standard or probe in neurological and pharmacological assays.
• Process Chemistry Development: Utilized in scaling up and optimizing synthetic routes for new chemical entities (NCEs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services.
• Academic Research: Employed in university and institutional labs for neuroscience and organic synthesis projects.

Basic Information

Product Name	2-[4-(3-Methoxyphenyl)Piperazin-1-Yl]-5-Nitrobenzonitrile
CAS No.	945299-91-2
Molecular Formula	C19H20N4O3
Molecular Weight	352.39 g/mol
Synonyms	5-Nitro-2-[4-(3-methoxyphenyl)-1-piperazinyl]benzonitrile; 2-(4-(3-Methoxyphenyl)piperazin-1-yl)-5-nitrobenzonitrile; 945299-91-2; 2-[4-(3-methoxyphenyl)piperazin-1-yl]-5-nitrobenzonitrile; 5-Nitro-2-[4-(3-methoxyphenyl)piperazinyl]benzonitrile; Benzonitrile, 2-[4-(3-methoxyphenyl)-1-piperazinyl]-5-nitro-; 2-(4-(3-Methoxyphenyl)piperazin-1-yl)-5-nitro-benzonitrile
EINECS	Contact for details

Quality Control

Our 2-[4-(3-Methoxyphenyl)Piperazin-1-Yl]-5-Nitrobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP guidelines for intermediates, as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.