Description

3-(Difluoromethyl)-5H,6H,7H,8H-[1,2,4]Triazolo[4,3-A]Pyrazine is a high-value heterocyclic building block containing both a difluoromethyl group and a fused triazolopyrazine core. This unique molecular architecture makes it a critical intermediate for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules with potential biological activity.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Research: Used in the discovery and development of new fungicides and herbicides, leveraging the bioactivity of the triazole and pyrazine motifs.
• Chemical Biology Probe Development: Acts as a scaffold for creating tool compounds to study enzyme function and biological pathways.
• Material Science Precursor: Potential use in the synthesis of advanced organic materials and ligands for catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	3-(Difluoromethyl)-5H,6H,7H,8H-[1,2,4]Triazolo[4,3-A]Pyrazine
CAS No.	945262-35-1
Molecular Formula	C7H8F2N4
Molecular Weight	186.16 g/mol
Synonyms	3-(Difluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine; [1,2,4]Triazolo[4,3-a]pyrazine, 5,6,7,8-tetrahydro-3-(difluoromethyl)-; 5,6,7,8-Tetrahydro-3-(difluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine; 3-Difluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine; Difluoromethyl-triazolopyrazine; CAS 945262-35-1
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethyl)-5H,6H,7H,8H-[1,2,4]Triazolo[4,3-A]Pyrazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure high consistency and reliability for your sensitive R&D and scale-up processes. Certificates of Analysis (COA) with detailed specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.