Description

2-Iodo-5-Methoxypyrazine is a halogenated pyrazine derivative, a versatile and high-value building block in advanced organic synthesis. Its unique structure, featuring both an iodine substituent and a methoxy group on the pyrazine ring, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, particularly for developing active pharmaceutical ingredients (APIs), specialty ligands, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used to create advanced fungicides, herbicides, and insecticides where the pyrazine core contributes to biological activity.
• Ligand and Catalyst Development: Serves as a building block for synthesizing specialized ligands used in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the development of organic semiconductors, conductive polymers, and other electronic materials due to its electron-deficient aromatic system.
• Chemical Research & Development: A valuable reagent for cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution, enabling structural diversification in R&D.
• Flavor & Fragrance Chemistry: Potential use as an intermediate for synthesizing high-value aroma chemicals, given the importance of methoxypyrazines in flavor profiles.

Basic Information

Product Name	2-Iodo-5-Methoxypyrazine
CAS No.	942624-06-8
Molecular Formula	C5H5IN2O
Molecular Weight	236.01 g/mol
Synonyms	5-Methoxy-2-iodopyrazine; 2-Iodo-5-methoxypyrazine; Iodomethoxypyrazine; Pyrazine, 2-iodo-5-methoxy-; 942624-06-8; 5-Methoxy-2-iodo-1,4-diazine
EINECS	Contact for details

Quality Control

Our 2-Iodo-5-Methoxypyrazine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality system supports development from laboratory to commercial scale, ensuring reliable supply for critical R&D and manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.