Description

5-Nitro-2-(Piperidin-4-Ol-1-Yl)Benzoic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its distinct benzoic acid core substituted with a nitro group and a piperidin-4-ol moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for synthesizing novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas requiring complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-infective targets.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex organic molecules requiring a functionalized benzoic acid derivative.
• Bioconjugation & Probe Development: The carboxylic acid and aromatic nitro groups provide handles for conjugation, useful in developing biochemical probes and labeled compounds.
• Academic & Institutional R&D: Serves as a research chemical for investigating new organic reactions and synthetic methodologies in university and institutional laboratories.

Basic Information

Product Name	5-Nitro-2-(Piperidin-4-Ol-1-Yl)Benzoic Acid
CAS No.	942474-93-3
Molecular Formula	C₁₃H₁₆N₂O₅
Molecular Weight	280.28 g/mol
Synonyms	5-Nitro-2-(4-hydroxypiperidin-1-yl)benzoic acid; 2-(4-Hydroxy-1-piperidinyl)-5-nitrobenzoic acid; Benzoic acid, 5-nitro-2-(4-hydroxy-1-piperidinyl)-; 942474-93-3; 5-Nitro-2-(4-hydroxypiperidino)benzoic acid; 1-(2-Carboxy-4-nitrophenyl)-4-hydroxypiperidine; 4-Hydroxy-1-(2-carboxy-4-nitrophenyl)piperidine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Each batch is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) are available upon request, detailing all relevant specifications. We adhere to a strict quality management system to guarantee the reliability required for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.