Description

cis-4-(Azetidin-3-Yl)-2,2-Dimethylmorpholine is a high-purity, advanced pharmaceutical intermediate featuring a unique fused morpholine-azetidine scaffold. This compound is valued for its role as a key building block in the synthesis of novel, small-molecule drug candidates, particularly in therapeutic areas requiring complex heterocyclic chemistry. It is primarily sought by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug molecules targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Used in the development and optimization of robust synthetic routes for API manufacturing under cGMP conditions.
• Ligand & Catalyst Development: The azetidine and morpholine moieties can be utilized to develop novel ligands for catalysis or as components in metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the design of molecular probes to study biological pathways and enzyme functions.

Basic Information

Item	Details
Product Name	cis-4-(Azetidin-3-Yl)-2,2-Dimethylmorpholine
CAS No.	942400-34-2
Molecular Formula	C9H18N2O
Molecular Weight	170.25 g/mol
Synonyms	2,2-Dimethyl-4-(azetidin-3-yl)morpholine; 4-(Azetidin-3-yl)-2,2-dimethylmorpholine; cis-2,2-Dimethyl-4-(azetidin-3-yl)morpholine; 942400-34-2; Azetidine, 3-(2,2-dimethyl-4-morpholinyl)-, cis-; (3S,4R)-2,2-Dimethyl-4-(azetidin-3-yl)morpholine (for specific stereoisomer); (3R,4S)-2,2-Dimethyl-4-(azetidin-3-yl)morpholine (for specific stereoisomer)
EINECS	Contact for details

Quality Control

Our cis-4-(Azetidin-3-Yl)-2,2-Dimethylmorpholine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformity to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (cis-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.