Description

Acetamide, 2-[2-[4-[(R)-(4-Chlorophenyl)Phenylmethyl]-1-Piperazinyl]Ethoxy]-, Hydrochloride (1:2) is a high-purity, non-racemic chiral compound of significant interest in advanced pharmaceutical research and development. This molecule matters as a sophisticated chemical intermediate, offering a defined stereocenter and specific pharmacophore for creating targeted bioactive molecules. It is primarily needed by pharmaceutical companies and advanced research institutions engaged in the synthesis of novel therapeutic agents, particularly within central nervous system (CNS) and receptor-targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel, chirally pure active pharmaceutical ingredients (APIs).
• Neurological Research: Used in the development of compounds targeting specific neurotransmitter receptors (e.g., serotonin, dopamine) for CNS disorders.
• Preclinical Drug Development: Serves as a critical starting material or intermediate in medicinal chemistry campaigns for lead optimization.
• Chemical Biology Probes: Utilized in the creation of selective molecular probes to study protein-ligand interactions and signaling pathways.
• Process Chemistry: Employed in route scouting and scale-up studies for the efficient production of candidate drugs.
• Asymmetric Synthesis: Acts as a chiral template or auxiliary in stereoselective synthetic transformations.

Basic Information

Product Name	Acetamide, 2-[2-[4-[(R)-(4-Chlorophenyl)Phenylmethyl]-1-Piperazinyl]Ethoxy]-, Hydrochloride (1:2)
CAS No.	942199-02-2
Molecular Formula	C27H30ClN3O2 • 2HCl
Molecular Weight	542.37 g/mol (for the salt form)
Synonyms	2-[2-[4-[(R)-(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl]ethoxy]acetamide dihydrochloride; (R)-2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetamide hydrochloride (1:2); UNII-9P3H6Z4U4F; 9P3H6Z4U4F; (R)-Clemastine Impurity 5; Acetamide, 2-[2-[4-[(R)-(p-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]-, dihydrochloride
EINECS	Contact for details

Quality Control

Our Acetamide, 2-[2-[4-[(R)-(4-Chlorophenyl)Phenylmethyl]-1-Piperazinyl]Ethoxy]-, Hydrochloride (1:2) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and stored in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.