Description

4-(4-Pyrimidin-2-Yl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core linked to a pyrimidinyl-phenyl moiety. This compound is critical for the research and development of novel therapeutic agents, particularly in kinase inhibitor programs. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of targeted kinase inhibitors for oncology and inflammatory disease research.
• Chemical Synthesis: Serves as a versatile precursor for constructing complex heterocyclic compounds in medicinal chemistry.
• Biochemical Research: Used in the development of molecular probes and assay standards for studying enzyme inhibition and signal transduction pathways.
• Custom Synthesis: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific Active Pharmaceutical Ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for drug discovery projects and methodological studies in organic synthesis.

Basic Information

Product Name	4-(4-Pyrimidin-2-Yl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	942189-35-7
Molecular Formula	C19H24N4O2
Molecular Weight	340.42 g/mol
Synonyms	tert-Butyl 4-[4-(pyrimidin-2-yl)phenyl]piperazine-1-carboxylate; 4-(4-Pyrimidin-2-ylphenyl)piperazine-1-carboxylic acid tert-butyl ester; 1-Boc-4-(4-(pyrimidin-2-yl)phenyl)piperazine; 942189-35-7; 4-(4-Pyrimidin-2-yl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester; BOC-protected 4-(4-pyrimidin-2-ylphenyl)piperazine; 2-[4-(4-tert-Butoxycarbonylpiperazin-1-yl)phenyl]pyrimidine
EINECS	Contact for details

Quality Control

Our 4-(4-Pyrimidin-2-Yl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.