Description

tert-Butyl 4-Hydroxy-4-(1,3-Thiazol-2-yl)piperidine-1-carboxylate is a high-value, functionalized piperidine derivative that serves as a critical building block in modern synthetic chemistry. Its molecular architecture, featuring both a protected amine and a thiazole heterocycle, makes it an indispensable intermediate for the development of novel active pharmaceutical ingredients (APIs). This compound is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the synthesis of targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in areas targeting neurological disorders and infectious diseases.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization processes due to its versatile piperidine-thiazole scaffold.
• API Synthesis: Serves as a precursor in the multi-step synthesis of complex molecules intended for clinical evaluation and commercial production.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity advanced intermediates.

Basic Information

Product Name	tert-Butyl 4-Hydroxy-4-(1,3-Thiazol-2-yl)piperidine-1-carboxylate
CAS No.	942185-02-6
Molecular Formula	C13H20N2O3S
Molecular Weight	284.37 g/mol
Synonyms	1-Boc-4-hydroxy-4-(thiazol-2-yl)piperidine; 4-Hydroxy-4-(2-thiazolyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-hydroxy-4-(thiazol-2-yl)piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-hydroxy-4-(thiazol-2-yl)piperidine; 4-(Thiazol-2-yl)-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester; 2-(1-Boc-4-hydroxypiperidin-4-yl)thiazole; BOC-4-Hydroxy-4-(2-thiazolyl)piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Hydroxy-4-(1,3-Thiazol-2-yl)piperidine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with the standards expected for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider holding under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.